Definition of a picker maker - a person who makes the strong, leather attachments fitted to each side of a weaving loom, used to drive the shuttle across the loom.

Parish Records Manchester, Lancashire
Baptism August 11, 1805 John Blakeborough, parents John and Frances Blakeborough

Parish Records St Marys Church, Manchester, Lancashire
Marriage December 4, 1837
John Blakebarrow, full age, widower, picker maker, residence Half Street, father John Blakebarrow, clock maker and
Ann Mottershead, full age, spinster, 1 Mayes Street Manchester, father Robert Mottershead, carrier
by Banns
by Rt Keeling?, B.A., Curate
John Blakebarrow his mark, Ann Motthershead her mark
in the presence of A? S. McKie, B. Bond, and Thomas Clarke, Clerk of St. Mary’s

Since his second wife emigrated to Australia in 1853 with the children, it is probable he died before that date.

First wife of John Blakeborough

Parish Records Collegiate Church of Manchester
William Carson batchelor of this parish and Town of Manchester Draper
and Mary Ann Daniels of this parish and Town of Manchester spinster
were married in this church by banns
January 22, 1816
by Joseph Brookes
In the presence of Sarah Daniels and William Yates

Parish Records Manchester Cathedral
John Blagborough bachelor of this parish and town of Manchester Merchant and
Mary Ann Carson of this parish and town of Manchester widow
married by licence on November 15 1827
In the presence of William Royton, Sarah Daniels and ???? Varley

I’m not sure about this Mary Ann Daniels/Carson/Blagborough is the wife of the John Blakeborough in our family tree.
Reasons
1) The marriage is a few months after the baptism of John and Mary’s oldest child Frances. However this does happen.
2) John’s wife wife Mary is said to be 33 when she dies. This Mary would then be about 13 when the first marriage takes place. However perhaps this age is incorrect. A Mary Ann Daniel was baptised in Manchester on March 8 1801.
3) John’s profession is given as picker maker in all other records, yet for this marriage its given as merchant. However he may have manufactured pickers and sold them thus making him a merchant as well.

Parish Records St. Johns, Manchester
Buried September 17 1837 Mary wife of John Blakeborough, of Half Street, age 33, ceremony by Thomas Hutchinson

England Select Deaths and Burials
Mary Blakeborough
Marital Status: Married
Death Age: 33
Birth Date: 1804
Death Date: abt 1837
Burial Date: 17 Sep 1837
Burial Place: Manchester, Lancaster, England
Spouse: John Blakeborough

Others give her name as Ann Mothersill. Her death certificate says Motherwell
Second wife of John

Victoria, Australia Assisted and Unassisted Passenger Lists
Arrived on the Marion Moore, Melbourne, Australia, March 1854
Ann Blakeborough, age 45, matron, English nationality
[No first name listed, probably Sarah] Blakeborough, male child [probably should be female], age 12
[No first name listed, probably Jane (Mary)] Blakeborough, female child, age 11

Death Record
District of West Hotham in the Colony [Victoria, Australia]
June 17, 1883 Melbourne Benevolent Asylum, Town of Hotham [now North Melbourne], County of Mow???, Ann Blakeborough, laundress, female, 75 years, died of Chronic Bronchitis, duration not known, Dr Whitaker attending, father Robert Motherwell, profession not known, mother Elizabeth Motherwell, maiden name not known